{"product_id":"cardiometabolic-and-genetik-risk-factors-for-early-atherosclerosis","title":"Cardiometabolic and Genetik Risk Factors for Early Atherosclerosis","description":"Background: Overweight has become a major health issue in modern Western society. Obesity and a sedentary lifestyle are closely related to metabolic syndrome, its components and different stages of glucose metabolism impairment. These are well-known cardiovascular risk factors and they have also been related to early stages of atherosclerosis. \n\nThe independent roles of these particular risk factors in the development of atherosclerosis are not, however, fully understood. It is known that type 2 diabetes has a more pronounced effect on cardiovascular risk in women than in men. Therefore, it is reasonable to hypothesize that milder impairment in glucose metabolism and metabolic syndrome might also have similar sex-related differences in their relationships to early atherosclerosis. This has not been studied extensively Genetics is another field in cardiovascular research that has gained a tremendous amount of attention in recent years. Large genome-wide association studies have revealed several gene polymorphisms relating to cardiovascular risk. \n\nSeveral different studies have identified a genetic locus on chromosome 9p21.3 that has an influence on the risk of coronary heart disease. The single nucleotide polymorphism on chromosome 9p21.3 showing the strongest association with coronary heart disease is known as rs1333049. A polymorphism located in the promoter region of inflammatory cytokine interleukin-6, known as IL6?174 G\u0026gt;C, has been studied in a number of candidate gene studies. It has been associated with the incidence of cardiovascular events, such as myocardial infarction, and several risk factors for cardiovascular disease. \n\nInterleukin-6 is closely related to inflammation, which is believed to be the driving force behind metabolic syndrome, type 2 diabetes and the atherosclerosis process in general. Overall, the results regarding IL6?174 G\u0026gt;C genotype and its associations with cardiovascular risk have been very controversial. The role of these two above-mentioned genotypes in the early stages of atherosclerosis is not clear. Aims: In the present study, the independent associations of metabolic syndrome and different stages of glucose intolerance with the markers of early atherosclerosis were studied.","brand":"Tampere University Press","offers":[{"title":"Default Title","offer_id":32425985048676,"sku":"9789514483219","price":57.95,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/suomalainen-test.myshopify.com\/products\/cardiometabolic-and-genetik-risk-factors-for-early-atherosclerosis","provider":"Suomalainen Test","version":"1.0","type":"link"}