{"product_id":"pseudogenes-and-gene-duplications-tell-a-story-of-evolutionary-fates-of-animal-alpha-carbonic-anhydrases","title":"Pseudogenes and gene Duplications Tell A Story of Evolutionary fates of Animal Alpha Carbonic Anhydrases","description":"In this study I have examined two subfamilies within metazoan á-CAs, namely the GPI-linked á-CAs in vertebrates and all á-CAs in 12 fruit fly genomes. \n\nWithin the GPI-linked subfamily, we characterized biochemically the novel isozyme, murine CA XV, to show that it is a glycosylated, GPI-anchored, membrane protein, similar to CA IV. The expression of gene CA15 was seen in mouse kidney, testis, and brain, similar to human CA4. \n\nOur studies show that CA15 is a pseudogene in primates, with multiple defects seen in different species. Their analysis suggests that the inactivation and 'pseudogenization' of CA15 in primates was probably initiated by a mutation of one of the active-site histidines or an insertion near the active site.","brand":"Tampere University Press","offers":[{"title":"Default Title","offer_id":26556140978276,"sku":"9789514491979","price":57.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0048\/8207\/1652\/products\/9789514491979_72061_2048.jpg?v=1590794996","url":"https:\/\/suomalainen-test.myshopify.com\/products\/pseudogenes-and-gene-duplications-tell-a-story-of-evolutionary-fates-of-animal-alpha-carbonic-anhydrases","provider":"Suomalainen Test","version":"1.0","type":"link"}