{"product_id":"variable-expressions-of-adam-family-genes-in-tissues-and-cancer-cells","title":"Variable expressions of ADAM family genes in tissues and cancer cells","description":"Ectodomain shedding, the proteolytic processing of cell surface proteins is a fast and effective way of regulating cell adhesion, cell signaling, and gene expression. ADAMs have emerged as a major family of cellular proteinases implicated in the ectodomain shedding of growth factors, cytokines, receptors, and cell adhesion proteins. In addition to the catalytic zinc metalloprotease domain, the extracellular part of ADAMs contains characteristic disintegrin and cysteine-rich domains, which mediate cell adhesion and regulate the metalloprotease activity. The subcellular localization and the regulation and targeting of the proteolytic activity of ADAMs are controlled by their cytosolic tail. Furthermore, ADAMs can also mediate intercellular adhesion through integrins or inhibit integrin binding and\/or signaling. ADAMs are thus poised to regulate and mediate intercellular adhesion and\/or communication important for every cell in multicellular organisms. \n\nMany of the molecular functions shown to be mediated by ADAMs in non-neural cells have been implicated in the regulation of neuron-neuron and neuron-glial cell interactions. The regulation of cell adhesion, cell signaling, and gene expression is particularly important for the synaptic plasticity suggested to form the basis of the learning and memory. For example, ADAM-mediated alpha-processing of APP is required for normal synaptic regulation. On the other hand, misregulation of the ADAM-APP-processing activity has been associated with accumulation of beta-amyloid, a neurotoxic APP derivative, implicated in Alzheimer's disease. Furthermore, misregulated ADAM-activity has been linked to cancer progression. ADAM-mediated growth factor and adhesion protein shedding provide growth and migration signals for cancer cells. Hence, the characterization of the expression patterns of ADAMs and their mechanisms of regulation in the nervous system and in cancer cell lines may provide important information on the molecular interactions essential for normal brain functions and cancer progression.","brand":"Tampere University Press","offers":[{"title":"Default Title","offer_id":32446670143588,"sku":"9789514469800","price":47.95,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/suomalainen-test.myshopify.com\/products\/variable-expressions-of-adam-family-genes-in-tissues-and-cancer-cells","provider":"Suomalainen Test","version":"1.0","type":"link"}